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Merck
CN

370654

PKG Inhibitor

The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PKG Inhibitor, Protein Kinase G Inhibitor, RKRARKE

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About This Item

Empirical Formula (Hill Notation):
C38H74N18O10
Molecular Weight:
943.11
NACRES:
NA.77
UNSPSC Code:
12352200

Key Documents

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Product Name

PKG Inhibitor, The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: yes
Target Ki: 86 µM against protein kinase G
Cell permeable: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A more specific, reversible, and substrate competitive inhibitor of protein kinase G (Ki = 86 µM) relative to protein kinase A (Ki = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser32 to Ala32) of histone H2B (amino acids 29-35).
A specific, reversible, and substrate competitive inhibitor of PKG (Ki = 86 µM) relative to PKA (Ki = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser32 to Ala32) of histone H2B (amino acids 29-35).

Other Notes

Glass, D.B., et al. 1983. Biochem. J.213, 159.
H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH

Packaging

Yes

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karen G Wong et al.
Science advances, 10(11), eadm9518-eadm9518 (2024-03-13)
Extracellular signals are transmitted through kinase cascades to modulate gene expression, but it remains unclear how epigenetic changes regulate this response. Here, we provide evidence that growth factor-stimulated changes in the transcript levels of many responsive genes are accompanied by
Debarati Mukherjee et al.
Cancer research, 83(17), 2889-2907 (2023-06-19)
Triple-negative breast cancers (TNBC) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early-stage localized TNBC, the rate of distant recurrence remains high, and long-term survival outcomes remain poor. In a search

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