370674
Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt
Synonym(s):
Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt, Rp-8-Br-cGMPS, Na, PKG Inhibitor II
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About This Item
Empirical Formula (Hill Notation):
C10H10BrN5O6PS · Na
Molecular Weight:
462.15
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
lyophilized
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
assay
≥99% (HPLC)
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent cell-permeable, metabolically stable inhibitor of cGMP-dependent protein kinase (PKG). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases.
A potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; Ki = 4 µM). Acts as a cyclic nucleotide-gated channel agonist (EC50 = 173.5 µM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 µmol = 2.31 mg.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target Ki: 4 µM against protein kinase G (PKG)
Other Notes
Wei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol.117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol.253, 179.
Zhuo, M., et al. 1994. Nature368, 635.
Nakamura, A., et al. 1996. Br. J. Pharmacol.117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol.253, 179.
Zhuo, M., et al. 1994. Nature368, 635.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 370674-5UMOL | 04055977191691 |