370674
Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt
别名:
Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt, Rp-8-Br-cGMPS, Na, PKG Inhibitor II
方案
≥99% (HPLC)
质量水平
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
溶解性
water: 1 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A potent cell-permeable, metabolically stable inhibitor of cGMP-dependent protein kinase (PKG). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases.
A potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; Ki = 4 µM). Acts as a cyclic nucleotide-gated channel agonist (EC50 = 173.5 µM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 µmol = 2.31 mg.
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target Ki: 4 µM against protein kinase G (PKG)
其他说明
Wei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol.117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol.253, 179.
Zhuo, M., et al. 1994. Nature368, 635.
Nakamura, A., et al. 1996. Br. J. Pharmacol.117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol.253, 179.
Zhuo, M., et al. 1994. Nature368, 635.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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