Skip to Content
Merck
CN

Key Documents

View All Documentation

370679

Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).

Synonym(s):

Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt, Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C18H14BrN5O6PS · Na
CAS Number:
172806-20-1
Molecular Weight:
562.27
MDL number:
MFCD04037251
UNSPSC Code:
41106305
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
lyophilized
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥98% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na+].[P+]1(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4c(nc3Br)C(=O)[n]5c(nc(c5)c6ccccc6)N4)CO1)([S-])[O-]

InChI

1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31?;/m1./s1

InChI key

SVMPQLHYWRTQCX-WKKXCKAJSA-M

General description

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKG1α & 1β
Product does not compete with ATP.
Reversible: no
Target Ki: 30 nM against PKG1α & 1β

Other Notes

Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKUGTIN
370679-1UMOL04055977191714