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370695

GW1929

PPARγ agonist, crystalline solid

Synonym(s):

GW1929, PPAR Agonist V, PPARγ Agonist IV

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About This Item

Empirical Formula (Hill Notation):
C30H29N3O4
CAS Number:
196808-24-9
Molecular Weight:
495.57
MDL number:
MFCD04040003
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
crystalline solid
Storage condition:
OK to freeze, protect from light
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Product Name

GW1929, A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).

Quality Segment

100

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N([C@@H](Cc3ccc(cc3)OCCN(C)c4ncccc4)C(=O)O)c1c(cccc1)C(=O)c2ccccc2

InChI

1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1

InChI key

QTQMRBZOBKYXCG-MHZLTWQESA-N

General description

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine PPARγ and 6.2 nM for human PPARγ in cell-based transactivation assays).

Biochem/physiol Actions

Cell permeable: no
EC50 = 13 nM as peroxisome proliferator-activated receptor γ (PPARγ) agonist for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays
Primary Target
Peroxisome proliferator-activated receptor γ (PPARγ) agonist
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Han, S., et al. 2004. Clin. Cancer Res.10, 1911.
Willson, T.M., et al. 2000. J. Med. Chem.43, 527.
Brown, K.K., et al. 1999. Diabetes48, 1415.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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