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Merck
CN

371724

GPR119 Agonist, AS1269574

The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

GPR119 Agonist, AS1269574, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist

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About This Item

Empirical Formula (Hill Notation):
C13H14BrN3O
CAS Number:
330981-72-1
Molecular Weight:
308.17
UNSPSC Code:
51111800
NACRES:
NA.51
MDL number:
MFCD00298280

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InChI

1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)

SMILES string

BrC(C=C1)=CC=C1C2=NC(C)=CC(NCCO)=N2

InChI key

DUKPGOOUJNUIOI-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

amber

solubility

DMSO: >10 mg/mL

shipped in

ambient

Quality Level

100

General description

A pyrimidine compound that acts as an effective GPR119 agonist (EC50 = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.

Packaging

Packaged under inert gas

Other Notes

Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun.400, 437.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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