371818
G-Protein βγ Binding Peptide, mSIRK
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.
Synonym(s):
G-Protein βγ Binding Peptide, mSIRK, mSIRK, myr-SIRKALNILGYPDYD-OH
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About This Item
Empirical Formula (Hill Notation):
C93H150N20O25
Molecular Weight:
1948.31
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
lyophilized
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Level
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
Biochem/physiol Actions
Cell permeable: yes
EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
Primary Target
N-myristoylated G-protein βγ selective binding
N-myristoylated G-protein βγ selective binding
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
Other Notes
Myr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Zhi-Wei Zhang et al.
Molecular medicine reports, 21(2), 720-730 (2020-01-25)
In the present study, the mechanism by which carboxyl terminal activating region 3 (CTAR3) of latent membrane protein 1 (LMP1), encoded by the Epstein‑Barr virus, regulated cell proliferation and protein expression was investigated in the nasopharyngeal epithelial cell line NP69.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 371818-1MG | 04055977213423 |
| 371818-5MG | 04055977213430 |