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371955-M

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

Name: H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
Brand: MM

A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor.

Synonym(s):

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem, 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₇N₃O₂S · 2HCl

CAS Number:

108930-17-2

Molecular Weight:

364.29

UNSPSC Code:

12352200

MDL number:

MFCD00036961

Assay:

≥98% (TLC)

Form:

lyophilized solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

water: 20 mg/mL

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N3C(CNCC3)C)c1c2c(cncc2)ccc1.[Cl-].[Cl-].[H+].[H+]

InChI

1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H

InChI key

OARGPFMFRLLKPF-UHFFFAOYSA-N

Description

General description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (K_i = 97 µM), protein kinase A (K_i = 3.0 µM), protein kinase C (K_i = 6 µM), and protein kinase G (K_i = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Primary Target
MLCK

Target K_i: 3.0 µM, 97 µM, 6.0 µM, 5.8 µM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

Further dilute with aqueous buffers just prior to use.

Other Notes

Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
Jarvis, W.D., et al. 1994. Cancer Res.54, 1707.
Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap.263, 1334.
Gimond, C., et al. 1992. Exp. Cell Res.203, 365.
Quick, J., et al. 1992. Biochem. Biophys. Res. Commun.187, 657.
Bouli, N.M., and Davis, M. 1990. Brain Res.525, 198.
Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther.255, 1218.
Schachtele, C., et al. 1988. Biochem. Biophys.Res. Commun.151, 542.
Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun.125, 258.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c