372770
HBDDE
A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.
Synonym(s):
HBDDE, 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether
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About This Item
Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
Molecular Weight:
338.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange
solubility
ethanol: 1 mg/mL, warm water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
O(Cc1c(c(c(c(c1)O)O)O)c2c(c(c(cc2COC)O)O)O)C
InChI
1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3
InChI key
NEBCAMAQXZIVRE-UHFFFAOYSA-N
General description
A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI, and βII isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
Protein kinase C (PKC) inhibitor. Selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI and βII isozymes.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKCα
PKCα
Product does not compete with ATP.
Reversible: no
Target IC50: 43 µM against PKCα
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Curtis B Read et al.
mBio, 15(4), e0029924-e0029924 (2024-02-28)
Many intracellular pathogens structurally disrupt the Golgi apparatus as an evolutionarily conserved promicrobial strategy. Yet, the host factors and signaling processes involved are often poorly understood, particularly for Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis. We found that A.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 372770-1MG | 04055977212884 |