质量水平
方案
≥95% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
orange
溶解性
ethanol: 1 mg/mL
warm water: 1 mg/mL
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
O(Cc1c(c(c(c(c1)O)O)O)c2c(c(c(cc2COC)O)O)O)C
InChI
1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3
InChI key
NEBCAMAQXZIVRE-UHFFFAOYSA-N
一般描述
A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI, and βII isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
Protein kinase C (PKC) inhibitor. Selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI and βII isozymes.
生化/生理作用
Cell permeable: yes
Primary Target
PKCα
PKCα
Product does not compete with ATP.
Reversible: no
Target IC50: 43 µM against PKCα
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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