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Merck
CN

376817-M

Hexokinase II Inhibitor II, 3-BP

The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

Hexokinase II Inhibitor II, 3-BP, 3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid

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About This Item

Empirical Formula (Hill Notation):
C3H3BrO3
CAS Number:
1113-59-3
Molecular Weight:
166.96
UNSPSC Code:
12352200
EC Index Number:
214-206-5
MDL number:
MFCD00002587
NACRES:
NA.77

Key Documents

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SMILES string

BrCC(=O)C(=O)O

InChI

1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)

InChI key

PRRZDZJYSJLDBS-UHFFFAOYSA-N

description

RTECS - UZ0840000

assay

≥97% (titration)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 100 mg/mL, distilled water: 100 mg/mL

Quality Level

100

Related Categories

General description

A cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bujis, M., et al. 2009. Invest. New Drugs27, 120.
Chen, Z., et al. 2009. Biochim. Biophys. Acta.1787, 553.
Hulleman, E., et al. 2009. Blood.113, 2014;
Mathupala, S.P., et al. 2009. Semin. Cancer Biol.19, 17.
Pereira da Silva, A.P., et al. 2009. Biochem. J.417, 717.
Yun, J., et al. 2009. Science.325, 1555.
Zhang, X., et al. 2009. Anticancer Res.29, 1443.
Kim, J.S., et al. 2008. J. Bioenerg. Biomembr.40, 607.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Corrosive (L)

hcodes

H314

pictograms

Corrosion
GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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