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377980

Hispidin

Name: Hispidin
Brand: MM

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC₅₀ = 2 µM).

Synonym(s):

Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₀O₅

CAS Number:

555-55-5

Molecular Weight:

246.22

UNSPSC Code:

12352200

MDL number:

MFCD01866972

Assay:

≥90% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+

InChI key

QISBNGLMCHHHFG-HNQUOIGGSA-N

Description

General description

A potent, cell permeable, and reversible inhibitor of protein kinase C_β isoform (PKC_β; IC₅₀ = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKCβ

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2 µM against PKCβ

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c