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399275

Nω-Hydroxy-nor-L-arginine diacetate Salt

Name: N&#969;-Hydroxy-nor-L-arginine diacetate Salt
Brand: MM

≥97% (TLC), Arginase inhibitor, solid

Synonym(s):

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

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About This Item

Empirical Formula (Hill Notation):

C₅H₁₂N₄O₃ · 2C₂H₄O₂

CAS Number:

189302-40-7

Molecular Weight:

296.28

MDL number:

MFCD01318777

UNSPSC Code:

12352209

NACRES:

NA.77

Assay:

≥97% (TLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt, A potent, selective, competitive, and high affinity inhibitor of arginase.

Quality Segment

100

assay

≥97% (TLC)

form

solid

potency

2 μM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C

InChI key

PQFYTZJPYBMTCT-QTNFYWBSSA-N

Description

General description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Biochem/physiol Actions

Primary Target
arginase from rat liver

Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c