Key Documents

View All Documentation

400600

L-N⁵-(1-Iminoethyl)ornithine dihydrochloride

Name: L-N⁵-(1-Iminoethyl)ornithine dihydrochloride
Brand: MM

≥98% (TLC), solid, eNOS inhibitor, Calbiochem^®

Synonym(s):

L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride, L-NIO, 2HCl

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₇H₁₅N₃O₂ · 2HCl

CAS Number:

159190-44-0

Molecular Weight:

246.13

MDL number:

MFCD09878280

UNSPSC Code:

12352209

NACRES:

NA.77

Assay:

≥98% (TLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride, A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.

Quality Segment

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C7H15N3O2.2ClH/c1-5(8)10-4-2-3-6(9)7(11)12;;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);2*1H/t6-;;/m0../s1

InChI key

RYCMAAFECCXGHI-ILKKLZGPSA-N

Description

General description

A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC₅₀ = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC₅₀ = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC₅₀ = 19.5 mg/kg).

Cell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC₅₀ = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC₅₀ = 19.5 mg/kg).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
eNOS

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 500 nM against endothelial nitric oxide synthase (eNOS); 2 µM against acetylcholine-induced relaxation of rat aorta rings; EC50 = 19.5 mg/kg for a dose-dependent increase in mean arterial blood pressure in the rat

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
Rees, D.D., et al. 1990. Br. J. Pharmacol.101, 746.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c