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Merck
CN

401474

IKK Inhibitor II, Wedelolactone

The IKK Inhibitor II, Wedelolactone, also referenced under CAS 65646-68-6, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

IKK Inhibitor II, Wedelolactone, Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan

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About This Item

Empirical Formula (Hill Notation):
C16H10O7
CAS Number:
524-12-9
Molecular Weight:
314.25
MDL number:
MFCD07778564
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow-green

solubility

methanol: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3

InChI key

XQDCKJKKMFWXGB-UHFFFAOYSA-N

General description

Cell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50<10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
IKKα and β kinase activity
Product does not compete with ATP.
Reversible: no
Target IC50: <10 µM against IKKα and β kinase activity

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kobori, M., et al. 2004. Cell Death Differ.11, 123.
Li, C.C., et al. 2003. J. Org. Chem.68, 8500.
Mors, W.B., et al. 1989. Toxicon27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med.5, 374.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Certificates of Analysis (COA)

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Ye Eun Jeong et al.
Annals of clinical and translational neurology, 10(2), 246-265 (2022-12-28)
Neurodegeneration induced by inflammatory stress in multiple sclerosis (MS) leads to long-term neurological disabilities that are not amenable to current immunomodulatory therapies. Here, we report that neuronal downregulation of Splicing factor 3b subunit 2 (SF3B2), a component of U2 small

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