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407616

IL-1R Antagonist

Name: IL-1R Antagonist
Brand: MM

≥95% (HPLC), Interleukin-1 receptor antagonist, oil

Synonym(s):

IL-1R Antagonist, BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₆N₂O₂

CAS Number:

566914-00-9

Molecular Weight:

302.41

MDL number:

MFCD06411423

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

oil

Quality level:

100

Storage condition:

OK to freeze

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Product Name

IL-1R Antagonist, The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.

Quality Level

100

assay

≥95% (HPLC)

form

oil

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

colorless

solubility

DMSO: 10 mg/mL, ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

N2(CCCC2)C(=O)[C@@H](NC(=O)CCc1ccccc1)C(C)C

InChI

1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,19,21)/t17-/m0/s1

InChI key

DAZSWUUAFHBCGE-KRWDZBQOSA-N

Related Categories

Bioactive Small Molecules

General description

A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
TIR domain-mediated MyD88/IL1-RI interaction

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice.

Shiqin Xiong et al.

Arteriosclerosis, thrombosis, and vascular biology, 41(11), 2773-2785 (2021-09-10)

[Figure: see text].

Global Trade Item Number

SKU	GTIN
407616-25MG	04055977211344
407616-10MG	04055977211337

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