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Merck
CN

407616

IL-1R Antagonist

≥95% (HPLC), Interleukin-1 receptor antagonist, oil

Synonym(s):

IL-1R Antagonist, BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

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About This Item

Empirical Formula (Hill Notation):
C18H26N2O2
CAS Number:
566914-00-9
Molecular Weight:
302.41
MDL number:
MFCD06411423
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

IL-1R Antagonist, The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.

SMILES string

N2(CCCC2)C(=O)[C@@H](NC(=O)CCc1ccccc1)C(C)C

InChI

1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,19,21)/t17-/m0/s1

InChI key

DAZSWUUAFHBCGE-KRWDZBQOSA-N

assay

≥95% (HPLC)

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

colorless

solubility

DMSO: 10 mg/mL
ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TIR domain-mediated MyD88/IL1-RI interaction
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.

Other Notes

Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shiqin Xiong et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(11), 2773-2785 (2021-09-10)
[Figure: see text].

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