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Merck
CN

407709

Insulin, Zinc, Human, Recombinant, P. pastoris

Synonym(s):

Insulin, Zinc, Human, Recombinant, P. pastoris

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About This Item

CAS Number:
11061-68-0
MDL number:
MFCD00131380
UNSPSC Code:
12352202
NACRES:
NA.77
Biological source:
yeast (Pichia pastoris)
Form:
solid
Assay:
≥95—105%

Key Documents

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biological source

yeast (Pichia pastoris)

Quality Level

200

description

Merck USA index - 14, 4980

sterility

non-sterile

Assay

≥95—105%

form

solid

specific activity

≥25 IU/mg (dry basis)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

<10 EU/mg Endotoxin (EU/mg protein)

color

white to off-white

solubility

0.01 M HCl: soluble

shipped in

wet ice

storage temp.

−20°C

InChI key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Related Categories

General description

Recombinant, human insulin (zinc) expressed in P. pastoris. Peptide anabolic hormone produced by pancreatic β-cells. Increases the synthesis of protein, fat, glycogen, and substrate oxidation in mitochondria. Interacts with membrane insulin receptor to cause its biological actions.

Preparation Note

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
Insulin is practically insoluble from pH 4.5-7.0.

Other Notes

Mohan, C., et al. 1989. Curr. Topics Cell. Reg.30, 105.
Johnson, I.S. 1983. Science219, 632.
≥25 IU/mg (dry basis).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

nwg

Regulatory Information

高风险级别生物产品-Merck
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Mohan Sreelekshmi et al.
Journal of biochemical and molecular toxicology, 35(6), 1-8 (2021-03-03)
Glucokinase (GK), a key regulator of hepatic glucose metabolism in the liver and glucose sensor and mediator in the secretion of insulin in the pancreas, is not studied in detail for its therapeutic application in diabetes. Herein, we study the
Medha Sharma et al.
Cell communication and signaling : CCS, 20(1), 179-179 (2022-11-16)
The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells. PHLPP isoforms were either silenced or overexpressed individually, and the effects were observed on individual Akt
Yamini Yadav et al.
The FEBS journal, 289(23), 7561-7581 (2022-07-11)
PP2Cα is one of the newly identified isoforms of metal-dependent protein phosphatases (PPM). The role of this phosphatase in neuronal insulin signalling is completely unknown. In the present study, we show insulin-mediated rapid upregulation of a protein of the insulin
Kerrie A Morrison et al.
Scientific reports, 12(1), 3532-3532 (2022-03-05)
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins. Here we report the first
Leying Chen et al.
eLife, 11 (2022-03-25)
Anti-epidermal growth factor receptor (EGFR) therapy-associated cutaneous toxicity is a syndrome characterized by papulopustular rash, local inflammation, folliculitis, and microbial infection, resulting in a decrease in quality of life and dose interruption. However, no effective clinical intervention is available for
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