Key Documents

View All Documentation

420107-M

Jasplakinolide

Name: Jasplakinolide
Brand: MM

from Jaspis johnstoni, ≥95% (HPLC), F-actin modulator, solid

Synonym(s):

Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₃₆H₄₅BrN₄O₆

CAS Number:

102396-24-7

Molecular Weight:

709.67

UNSPSC Code:

12352200

MDL number:

MFCD00873735

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Jasplakinolide, Jaspis johnstoni, A cell-permeable F-actin probe.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

InChI

1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22+,23-,24-,30+,31+/m0/s1

InChI key

GQWYWHOHRVVHAP-HZIRKPFGSA-N

Description

General description

A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca²⁺entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (K_d = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.

Biochem/physiol Actions

Kd = 15 nM for actin binding

Primary Target
Inducer of actin polymerization and stabilization in vitro

Other Notes

Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Still not finding the right product?

Explore all of our products under Jasplakinolide, Jaspis johnstoni

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)