420123-M
JNK Inhibitor II, Negative Control
The JNK Inhibitor II, Negative Control, also referenced under CAS 54642-23-8, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
JNK Inhibitor II, Negative Control, N¹-Methyl-1,9-pyrazoloanthrone
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About This Item
Empirical Formula (Hill Notation):
C15H10N2O
CAS Number:
Molecular Weight:
234.25
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.28
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
storage temp.
−20°C
General description
A useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
Biochem/physiol Actions
Primary Target
A useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
A useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
Target IC50: 18 µM and 24 µM against JNK2 and JNK3, respectively
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
Other Notes
Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta1589, 311.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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