420305
K-252c
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC50 = 2.45 µM) and protein kinase A (IC50 = 25.7 µM).
Synonym(s):
K-252c
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About This Item
Empirical Formula (Hill Notation):
C20H13N3O
CAS Number:
Molecular Weight:
311.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 5 mg/mL, methanol: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
[nH]1c2c3[nH]c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4
InChI
1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
InChI key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
General description
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (IC50 = 25.7 µM) and protein kinase C (IC50 = 2.45 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
PKC
Product competes with ATP.
Reversible: yes
Target IC50: 2.45 µM against protein kinase C
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Nakanishi, S., et al. 1986. J. Antibiot. 39, 1066.
Nakanishi, S., et al. 1986. J. Antibiot. 39, 1066.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 420305-1MG | 04055977210927 |