420305
K-252c
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC50 = 2.45 µM) and protein kinase A (IC50 = 25.7 µM).
别名:
K-252c
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H13N3O
化学文摘社编号:
分子量:
311.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[nH]1c2c3[nH]c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4
InChI
1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
InChI key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 5 mg/mL, methanol: soluble
shipped in
ambient
Quality Level
General description
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (IC50 = 25.7 µM) and protein kinase C (IC50 = 2.45 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
PKC
Product competes with ATP.
Reversible: yes
Target IC50: 2.45 µM against protein kinase C
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Nakanishi, S., et al. 1986. J. Antibiot. 39, 1066.
Nakanishi, S., et al. 1986. J. Antibiot. 39, 1066.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持