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420311

Kanamycin Sulfate, Streptomyces kanamyceticus

An aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms.

Synonym(s):

Kanamycin Sulfate, Streptomyces kanamyceticus, Kamycin

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About This Item

Empirical Formula (Hill Notation):
C18H36N4O11 · xH2SO4
CAS Number:
25389-94-0
Molecular Weight:
484.50 (free base basis)
UNSPSC Code:
51281654
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
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Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

General description

Contains more than 98% kanamycin A. An aminoglycoside antibiotic affective against gram-positive and gram-negative organisms. Inhibitor of protein biosynthesis that acts on the 70S ribosome, causing misreading of the genetic code. May cause renal damage and ototoxicity.
Potency: ≥750 µg/mg

Biochem/physiol Actions

Primary Target
protein biosynthesis

Preparation Note

Following reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1 (Ausubel, F.M., et al., eds.) John Wiley & Sons, New York.
Kahn, R.W., et al. 1993. Proc. Natl. Acad. Sci. USA90, 9295.
Cardon, G.H., et al. 1993. Plant J.3, 773.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York. p.1.6, A.6.
Korzybyski, T., et al. 1978. In Antibiotics, Origin, Nature, and Properties1, 690.
Stiffler, P.W., et al. 1974. Antimicrob. Agents Chemother.6, 516.
Umezawa, S., et al. 1968. J. Antibiot.21, 367.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
420311-25GM07790788050115
420311-5GM07790788050139