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KT5823

Name: KT5823
Brand: MM

≥98% (HPLC), Protein Kinase G inhibitor, solid

Synonym(s):

KT5823, PKG Inhibitor VII

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₂₅N₃O₅

CAS Number:

126643-37-6

Molecular Weight:

495.53

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD09878278

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Product Name

KT5823, Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 1 mg/mL, DMF: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CN(C7=O)C)cccc6)[C@@H]5O[C@]1([C@@](C5)(OC)C(=O)OC)C

InChI

1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1

InChI key

QTYMDECKVKSGSM-YMUMJAELSA-N

Description

General description

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM). Inhibits protein kinase C (K_i = 4.0 µM) and protein kinase A (K_i >10.0 µM) at higher concentrations.

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKG

Product competes with ATP.

Reversible: yes

Target K_i: 234 nM against protein kinase G

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Further dilute with aqueous buffers just prior to use.

Other Notes

Grider, J.R. 1993. Am. J. Physiol.264, G334.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c