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422706

KN-62

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.

Synonym(s):

KN-62, 1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II, 1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II

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About This Item

Empirical Formula (Hill Notation):
C38H35N5O6S2
CAS Number:
127191-97-3
Molecular Weight:
721.84
UNSPSC Code:
12352200
MDL number:
MFCD00083180
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

off-white

solubility

methanol: 5 mg/mL, DMSO: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3

InChI key

RJVLFQBBRSMWHX-UHFFFAOYSA-N

General description

A cell-permeable, reversible, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cam kinase 2
Product does not compete with ATP.
Reversible: yes
Target Ki: 900 nM for rat brain CaM kinase II

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Further dilute with aqueous buffer just prior to use.

Other Notes

Minami, H., et al. 1994. Biochem. Biophys. Res. Commun.199, 241.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
422706-1MG04055977187236