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427572

Bovine Lactosyl Ceramide

Name: Bovine Lactosyl Ceramide
Brand: MM

≥98% (TLC), solid, glycosphingolipid precursor, Calbiochem^®

Synonym(s):

Lactosyl Ceramide, Bovine, Galβ,1,4Glc-Cer, LacCer, LC, LC, Galβ,1,4Glc-Cer, LacCer

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About This Item

Empirical Formula (Hill Notation):

C₅₃H₁₀₁NO₁₃

CAS Number:

4682-48-8

Molecular Weight:

960.37

UNSPSC Code:

12352211

NACRES:

NA.77

MDL number:

MFCD00133445

Assay:

≥98% (TLC)

Form:

solid

Storage condition:

OK to freeze

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Properties

Product Name

Lactosyl Ceramide, Bovine, A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL.

Quality Segment

100

description

RTECS - FK1000000

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

colorless

solubility

ethanol: 1 mM, methanol: 1 mM

shipped in

ambient

storage temp.

−20°C

SMILES string

N(C(C(O)\C=C\CCCCCCCCCCCCC)CO[C@@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)OC2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)CO)C(=O)CCCCCCCCCCCCCCCCC

InChI

1S/C48H91NO13/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-40(53)49-36(37(52)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)35-59-47-45(58)43(56)46(39(34-51)61-47)62-48-44(57)42(55)41(54)38(33-50)60-48/h29,31,36-39,41-48,50-52,54-58H,3-28,30,32-35H2,1-2H3,(H,49,53)/b31-29+/t36?,37?,38-,39-,41+,42+,43-,44-,45-,46+,47-,48?/m1/s1

InChI key

VOZHMDQUIRUFQW-AIRKALMMSA-N

Description

General description

A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, and c-fos expression in human aortic smooth muscle cells.

A neutral glycosphingolipid (GSL) which is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco- series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase and c-fos expression in human aortic smooth muscle cells.

Molecular weight: 960.4 (based on tricosanyl -23:0)

M.W. 960.4 (based on tricosanoyl - 23:0).

Biochem/physiol Actions

Cell permeable: no

Primary Target
A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Bhunia, A.K., et al. 1997. J. Biol. Chem.272, 15642.
Bhunia, A.K., et al. 1996. J. Biol. Chem.271, 10660.
Zacharias, C., et al. 1994. J. Biol. Chem.269, 13313.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c