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Merck
CN

440205-M

LY 83583

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM).

Synonym(s):

LY 83583, 6-Anilino-5,8-quinolinequinone

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About This Item

Empirical Formula (Hill Notation):
C15H10N2O2
CAS Number:
91300-60-6
Molecular Weight:
250.25
UNSPSC Code:
12352200
MDL number:
MFCD00210756
NACRES:
NA.77

Key Documents

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SMILES string

N(c3ccccc3)C1=CC(=O)c2ncccc2C1=O

InChI

1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H

InChI key

GXIJYWUWLNHKNW-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red-purple

solubility

ethanol: 3 mg/mL, acetone: soluble

Quality Level

100

Related Categories

General description

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.

Biochem/physiol Actions

Primary Target
soluble guanylate cyclase
Target IC50: 2 µM against soluble guanylate cyclase

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

Other Notes

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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