444170-M
Manumycin A, Streptomyces parvulus
An antibiotic with antitumor properties.
别名:
Manumycin A, Streptomyces parvulus
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关于此项目
Assay:
≥96% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥96% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow to brown
solubility
DMSO: 10 mg/mL, chloroform: soluble, methanol: soluble
storage temp.
2-8°C
InChI
1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
InChI key
TWWQHCKLTXDWBD-MVTGTTCWSA-N
General description
An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
Biochem/physiol Actions
Primary Target
Farnesyltransferase (FTAse)
Farnesyltransferase (FTAse)
Target IC50: 5 µM against farnesyltransferase (FTase); 180 µM against geranylgeranyltransferase I (GGTase I)
Preparation Note
Following reconstitution, aliquot and freeze (-20°C).
Other Notes
Kainuma, O., et al. 1997. Pancreas15, 379.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci.18, 349.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci.18, 349.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable