444170-M
Manumycin A, Streptomyces parvulus
An antibiotic with antitumor properties.
别名:
Manumycin A, Streptomyces parvulus
方案
≥96% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow to brown
溶解性
DMSO: 10 mg/mL
chloroform: soluble
methanol: soluble
储存温度
2-8°C
InChI
1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
InChI key
TWWQHCKLTXDWBD-MVTGTTCWSA-N
一般描述
An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
生化/生理作用
Primary Target
Farnesyltransferase (FTAse)
Farnesyltransferase (FTAse)
Target IC50: 5 µM against farnesyltransferase (FTase); 180 µM against geranylgeranyltransferase I (GGTase I)
制备说明
Following reconstitution, aliquot and freeze (-20°C).
其他说明
Kainuma, O., et al. 1997. Pancreas15, 379.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci.18, 349.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci.18, 349.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
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