444247
MMP Inhibitor II
The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
MMP Inhibitor II, N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C21H27N3O8S2
CAS Number:
Molecular Weight:
513.58
UNSPSC Code:
12352200
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25)
InChI key
MCSWSPNUKWMZHM-UHFFFAOYSA-N
General description
A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
A potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively
Packaging
Packaged under inert gas
Preparation Note
Requires vigorous vortexing for 60 seconds to completely solubilize the product.
Other Notes
Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 444247-1MG | 04055977186475 |