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444605

Melittin

>97% (HPLC), Calmodulin binder, lyophilized

Synonym(s):

Melittin

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About This Item

Empirical Formula (Hill Notation):
C131H229N39O31
CAS Number:
37231-28-0
Molecular Weight:
2846.46
MDL number:
MFCD00076868
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
>97% (HPLC)
Form:
lyophilized
Quality level:
100
Storage condition:
OK to freeze
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Product Name

Melittin, A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.

Quality Level

100

description

Merck USA index - 14, 5824

assay

>97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N1(C(CCC1)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(CC)C)C(=O)NC(CO)C(=O)NC(Cc2c3c([nH]c2)cccc3)C(=O)NC(C(CC)C)C(=O)NC(CCCCN)C(=O)NC(CCCN\C(=N\[H])\N)C(=O)NC(CCCCN)C(=O)NC(CCCN\C(=N\[H])\N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)N)C(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC

InChI

1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)

InChI key

VDXZNPDIRNWWCW-UHFFFAOYSA-N

General description

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C

Packaging

Yes

Other Notes

Fukushima, N., et al. 1998. Peptides19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun.133, 256.
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
444605-250UG04055977186130