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Merck
CN

444605

Melittin

>97% (HPLC), Calmodulin binder, lyophilized

别名:

Melittin

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关于此项目

经验公式（希尔记法）:
C131H229N39O31
化学文摘社编号:
37231-28-0
分子量:
2846.46
MDL number:
MFCD00076868
UNSPSC Code:
12352200
NACRES:
NA.77

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产品名称

Melittin, A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.

SMILES string

N1(C(CCC1)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(CC)C)C(=O)NC(CO)C(=O)NC(Cc2c3c([nH]c2)cccc3)C(=O)NC(C(CC)C)C(=O)NC(CCCCN)C(=O)NC(CCCN\C(=N\[H])\N)C(=O)NC(CCCCN)C(=O)NC(CCCN\C(=N\[H])\N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)N)C(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC

InChI

1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)

InChI key

VDXZNPDIRNWWCW-UHFFFAOYSA-N

description

Merck USA index - 14, 5824

assay

>97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Disclaimer

Toxicity: Standard Handling (A)

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C

General description

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.

Other Notes

Fukushima, N., et al. 1998. Peptides19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun.133, 256.
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂

Packaging

Yes

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

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