474705
Mevastatin, Sodium Salt
Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.
Synonym(s):
Mevastatin, Sodium Salt
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About This Item
Empirical Formula (Hill Notation):
C23H35O6 · Na
Molecular Weight:
430.51
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Segment
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
ethanol: 20 mg/mL, DMSO: 30 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G1 phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).
Biochem/physiol Actions
Cell permeable: no
Primary Target
HMG-CoA reductase
HMG-CoA reductase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.
Endo, A. 1992. J. Lipid Res.33, 1569.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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