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475874-M

MK571, Sodium Salt

≥90% (HPLC), leukotriene D4receptor antagonist, solid

Synonym(s):

MK571, Sodium Salt, L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt

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About This Item

Empirical Formula (Hill Notation):
C26H26ClN2O3S2 · Na
CAS Number:
115104-28-4
Molecular Weight:
537.07
MDL number:
MFCD00797675
UNSPSC Code:
12352211
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated
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Product Name

MK571, Sodium Salt, A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

Quality Level

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

off-white

solubility

DMSO: 10 mg/mL, water: 200 mg/mL

storage temp.

−20°C

SMILES string

S(C(SCCC(=O)O)c1cc(ccc1)\C=C\c2nc3c(cc2)ccc(c3)Cl)CCC(=O)N(C)C

InChI

1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+

InChI key

AXUZQJFHDNNPFG-UXBLZVDNSA-N

General description

A selective, competitive antagonist of leukotriene D4 (LTD4) receptor (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).

Biochem/physiol Actions

Primary Target
Antagonist of leukotriene D4 (LTD4)
Target Ki: 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.

Other Notes

Olson, D.P., et al. 2001. Cytometry46, 105.
Van der Kolk, D.M., et al. 1998. Clin. Cancer Res.4, 1727.
Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol.67, 17.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
475874-5MG07790788050474