47589-M
Mitomycin C, Streptomyces caespitosus
Synonym(s):
Mitomycin C, Streptomyces caespitosus, Mitocin C, MMC
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C15H18N4O5
CAS Number:
Molecular Weight:
334.33
UNSPSC Code:
12352200
MDL number:
assay
≥95% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
blue-violet
solubility
water: 1 mg/mL
storage temp.
2-8°C
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
General description
Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase.
Physical form
Provided as 2 mg antibiotic and 48 mg NaCl.
Preparation Note
Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
Other Notes
Kruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899.
Malkinson, A.M., et al. 1992. Cancer Res.52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471.
Tomasz, M., et al. 1987. Science235, 1204.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899.
Malkinson, A.M., et al. 1992. Cancer Res.52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471.
Tomasz, M., et al. 1987. Science235, 1204.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
Regulatory Information
新产品
This item has
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 47589-2MG | 07790788050498 |
| 47589-2MG-M | 07790788050498 |