480030
NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control
A cell-permeable Antennapedia-NBD mutated fusion peptide analog of NEMO-Binding Domain Binding Peptide that serves as a negative control.
Synonym(s):
NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control, DRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
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About This Item
Empirical Formula (Hill Notation):
C154H249N47O42S
Molecular Weight:
3462.98
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Segment
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable Antennapedia-NBD mutated (Trp739 and Trp741 replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
A cell-permeable, Antennapedia-NBD mutated (Trp739 → Ala and Trp741 → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Negative control defective in binding to NEMO
Negative control defective in binding to NEMO
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
H₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
Jimi, E., et al. 2004. Nat. Med., 10, 617.
May, M.J., et al. 2000. Science289, 1550.
May, M.J., et al. 2000. Science289, 1550.
This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
flash_point_c
Not applicable
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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