480060
Necrosis Inhibitor, IM-54
The Necrosis Inhibitor, IM-54, also referenced under CAS 861891-50-1, selectively blocks oxidative stress-induced necrotic cell death. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Necrosis Inhibitor, IM-54, 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
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About This Item
Empirical Formula (Hill Notation):
C19H23N3O2
CAS Number:
Molecular Weight:
325.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow-orange
solubility
methanol: 10 mg/mL, DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N1(C(=O)C(=C(C1=O)c2c3c([n](c2)C)cccc3)NCCCCC)C
InChI
1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
InChI key
SGLOMINNEBLJFF-UHFFFAOYSA-N
General description
A cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Blocks oxidative stress-induced necrotic cell death
Blocks oxidative stress-induced necrotic cell death
Product does not compete with ATP.
Reversible: no
Target IC50: (~3 µM prevented ~50% cell death in HL60 cells exposed to 100 µM H₂O₂).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett.15, 3114.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Toria Tomasek et al.
Biochemical and biophysical research communications, 556, 199-206 (2021-04-14)
Circulating cell-free hemoglobin (CFH) contributes to endothelial injury in several inflammatory and hemolytic conditions. We and others have shown that CFH causes increased endothelial permeability, but the precise mechanisms of CFH-mediated endothelial barrier dysfunction are not fully understood. Based on
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 480060-5MG | 04055977201864 |