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480402

NFAT Inhibitor

Name: NFAT Inhibitor
Brand: MM

The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

NFAT Inhibitor, MAGPHPVIVITGPHEE

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About This Item

Empirical Formula (Hill Notation):

C₇₅H₁₁₈N₂₀O₂₂S

CAS Number:

249537-73-3

Molecular Weight:

1683.93

MDL number:

MFCD02683959

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](Cc5nc[nH]c5)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4nc[nH]c

InChI

1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)9

InChI key

QPMHUXBSHGAVGD-MCDIZDEASA-N

Description

General description

A highly selective NFAT (Nuclear Factor of Activated T-cells) inhibitor that interferes with calcineurin-NFAT interaction without affecting calcineurin (Cat. No. 539568) phosphatase activity. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.

A highly selective NFAT inhibitor that prevents NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells. Does not affect the expression of other cytokines requiring calcineurin, but not NFAT. Inhibits calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts.

Biochem/physiol Actions

Cell permeable: no

Primary Target
NFAT (Nuclear Factor of Activated T-cells)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

Noguchi, H., et al. 2004. Nat. Med.10, 305.
Kiani, A., et al. 2001. Blood98, 1480.
Aramburu, J., et al. 1999. Science285, 2129.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.

Sami I Said

Annals of the New York Academy of Sciences, 1144, 148-153 (2008-12-17)

Pulmonary vascular remodeling and inflammation often coexist in clinical and experimentally induced pulmonary arterial hypertension (PAH). In some instances, the pulmonary hypertension may be the primary, or at least the initial, problem, while inflammatory or autoimmune responses appear to initiate

Global Trade Item Number

SKU	GTIN
480402-500UG	07790788050658