480747
Neurogenesis Inducer V, KHS101
A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2).
Synonym(s):
Neurogenesis Inducer V, KHS101, N⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine
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About This Item
Empirical Formula (Hill Notation):
C18H21N5S
CAS Number:
Molecular Weight:
339.46
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
resin (Sticky)
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
resin (Sticky)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
[s]1c(nc(c1)CNc3nc(ccn3)NCC(C)C)c2ccccc2
InChI
1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23)
InChI key
DGRJOOOHPBSAHD-UHFFFAOYSA-N
General description
A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.
Packaging
Packaged under inert gas
Other Notes
Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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