481408-M
NF-κB Activation Inhibitor II, JSH-23
The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Synonym(s):
NF-κB Activation Inhibitor II, JSH-23, 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
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About This Item
Empirical Formula (Hill Notation):
C16H20N2
CAS Number:
Molecular Weight:
240.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL
storage temp.
−20°C
SMILES string
N(CCCc2ccccc2)c1c(cc(cc1)C)N
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
General description
A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
A cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC50 = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.
Biochem/physiol Actions
Primary Target
Blocks nuclear translocation of NF-κB p65 and its transcription activity
Blocks nuclear translocation of NF-κB p65 and its transcription activity
Target IC50: 7.1 µM in a NF-κB reporter assay using RAW 264.7
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shin, H.M., et al. 2004. FEBS Lett.571, 50.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
Certificates of Analysis (COA)
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