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Merck
CN

487920

S-Nitrosoglutathione

≥95% (HPLC), solid, nitric oxide carrier, Calbiochem®

Synonym(s):

S-Nitrosoglutathione, GSNO, SNOG

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About This Item

Empirical Formula (Hill Notation):
C10H16N4O7S
CAS Number:
57564-91-7
Molecular Weight:
336.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00214341

Key Documents

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Product Name

S-Nitrosoglutathione, A utility carrier of nitric oxide.

SMILES string

S(N=O)C[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O

InChI

1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1

InChI key

HYHSBSXUHZOYLX-WDSKDSINSA-N

description

RTECS - MC0558000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

pink

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
A utility carrier of nitric oxide
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A utility carrier of nitric oxide. Breaks down to produce nitric oxide and a glutathione radical at pH 7.4. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

Other Notes

Sandau, K., et al. 1996. Cell Signal.8, 173.
Askew, S.C. 1995. Bioorg. Med. Chem.3, 1.
Fehsel, K., et al. 1995. J. Immunol.155, 2858.
de Belder, A.J., et al. 1994. Cardiovasc. Res.28, 691.
Sexton, D.J., et al. 1994. Photochem. Photobiol.59, 463.
Singh, R.J., et al. 1994. FEBS Lett. 360, 47.
Merryman, P.F., et al. 1993. Arthritis Rheum.36, 1414.
Park, J.W., et al. 1993. Biochem. Mol. Biol. Int.30, 885.
Radomski, M.W., et al. 1992. Br. J. Pharmacol.107, 745.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C or for up to 2 h at 4°C.
Reconstitute in cold distilled H₂O (4°C) free of divalent cations other than Ca2+.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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