492030
NS 2028
Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.
别名:
NS 2028, 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
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关于此项目
经验公式（希尔记法）:
C9H5BrN2O3
化学文摘社编号:
分子量:
269.05
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated
Quality Segment
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white to off-white
solubility
chloroform: 1 mg/mL, DMSO: 5 mg/mL, ethanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Brc1cc2c(cc1)OCc3[n]2[c]([o]n3)=O
InChI
1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
InChI key
MUDRLQRJCGJJTB-UHFFFAOYSA-N
General description
Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
Biochem/physiol Actions
Cell permeable: no
Primary Target
basal soluble guanylyl cyclase
basal soluble guanylyl cyclase
Product does not compete with ATP.
Reversible: no
Target IC50: 30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
Other Notes
Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable