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5.05986

SR-95531

Name: SR-95531
Brand: MM

≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem^®

Synonym(s):

SR95531 (Gabazine), GABA _A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABA_A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₇N₃O₃ · xHBr

CAS Number:

104104-50-9

Molecular Weight:

287.31 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00055135

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Product Name

SR95531 (Gabazine),

assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

440 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 25 mM

storage temp.

2-8°C

SMILES string

[Br-].[N+H2]=C1N(N=C(C=C1)c2ccc(cc2)OC)CCCC(=O)O

InChI

1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChI key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

Description

General description

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (K_b = 190 µM).

Biochem/physiol Actions

Primary Target
GABA_A

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c