5.06239
Bupropion Hydrochloride
Synonym(s):
Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion
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About This Item
Empirical Formula (Hill Notation):
C13H18ClNO · xHCl
CAS Number:
Molecular Weight:
239.74 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Level
form
solid
potency
1.4 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: soluble
storage temp.
2-8°C
SMILES string
Clc1cc(ccc1)C(=O)C(NC(C)(C)C)C.Cl
InChI
1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
InChI key
HEYVINCGKDONRU-UHFFFAOYSA-N
General description
A non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
Biochem/physiol Actions
Primary Target
DAT/NET
DAT/NET
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.
Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.
Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 5062390001 | 04055977243185 |