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5.06271

Ketanserin Tartrate

Synonym(s):

Ketanserin Tartrate, 5-HT 2A Serotonin Receptor Antagonist, Ketanserin, R 41 468

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About This Item

Empirical Formula (Hill Notation):
C22H22FN3O3 · xC4H6O6
CAS Number:
83846-83-7
Molecular Weight:
395.43 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00084651
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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assay

≥97% (HPLC)

Quality Level

100

form

solid

potency

1.49 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: soluble

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4c(cccc4)C3=O.OC(C(O)C(=O)O)C(=O)O.O

InChI

1S/C22H22FN3O3.C4H6O6.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10;/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10);1H2

InChI key

KJJRKCWDAHTVRL-UHFFFAOYSA-N

General description

A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.

Biochem/physiol Actions

Primary Target
5-HT2A

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.
Leysen, J. E. et al. 1981. Life Sci.28, 1015.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Information

新产品

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Global Trade Item Number

SKUGTIN
506271000104055977243192