5.08508
Zonisamide
Synonym(s):
Zonisamide, AD 810, CI 912
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About This Item
Empirical Formula (Hill Notation):
C8H8N2O3S
CAS Number:
Molecular Weight:
212.23
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N)Cc1n[o]c2c1cccc2
InChI
1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
InChI key
UBQNRHZMVUUOMG-UHFFFAOYSA-N
General description
A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC50 = 24.8 µM). Displays neurprotective properties.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
Na+ and Ca2+ channels
Na+ and Ca2+ channels
Other Notes
Sonsalla, P.K., et al. 2010. Exp. Neurol.221, 329.
Sobieszek, G. et al. 2003. Pol. J. Pharmacol.55, 68.
Sobieszek, G. et al. 2003. Pol. J. Pharmacol.55, 68.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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