5.08773
PPACK, 2HCl
InSolution, ≥88%
Synonym(s):
InSolution PPACK, 2HCl, D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, 2HCl, H-D-Phe-Pro-Arg-chloromethylketone, 2HCl, PPACK, dihydrochloride InSolution
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About This Item
Empirical Formula (Hill Notation):
C21H31ClN6O3 · 2HCl
Molecular Weight:
523.88
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥88% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
Quality Segment
assay
≥88% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
storage temp.
−70°C
General description
D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) is a potent and specific inhibitor of thrombin with ideal, unbiased properties for use as an anticoagulant in blood gas, electrolyte, and iCa analyses.
Biochem/physiol Actions
Reversible: no
Packaging
Packaged under inert gas
Physical form
A 25 mM (5 mg/357 µl) sterile-filtered solution of PPACK, 2HCl (Cat. No. 520222) in H₂O.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Other Notes
Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry32, 4727.
Yamashita, T., et al. 1993. Thromb. Res.69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry32, 4727.
Yamashita, T., et al. 1993. Thromb. Res.69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
does not flash
flash_point_c
does not flash
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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