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5.09455

Etomoxir

Name: Etomoxir
Brand: MM

≥98% (HPLC), liquid, CPT-1 inhibitor, Calbiochem^®

Synonym(s):

InSolution Etomoxir, R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₈ClO₄ · Na

CAS Number:

828934-41-4

Molecular Weight:

320.74

MDL number:

MFCD07787411

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

liquid

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

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Properties

Product Name

Etomoxir, InSolution, ≥98%, 50 mM aqueous solution, shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity

Quality Segment

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

storage temp.

−70°C

SMILES string

[Na+].Clc1ccc(cc1)OCCCCCC[C@]2(OC2)C(=O)[O-]

InChI

1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1

InChI key

RPACBEVZENYWOL-XFULWGLBSA-M

Description

General description

A cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells at a concentration of 1-80 µM and 40 µM, respectively.

Biochem/physiol Actions

Primary Target
CPT1

Packaging

Packaged under inert gas

Physical form

A 50 mM (2 mg/118 µL) solution of Etomoxir (Cat. No. 236020) in H₂O.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Other Notes

Xu, F.Y., et al. 2003. J. Lipid Res.44, 415.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c