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5.09705

Sigma-Aldrich

L-Serine-O-phosphate

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Synonym(s):
L-Serine-O-phosphate, L-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-SOP, L-Serine O-phosphate
Empirical Formula (Hill Notation):
C3H8NO6P
CAS Number:
407-41-0
Molecular Weight:
185.07
MDL number:
MFCD00065935

Assay

≥98% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: 50 mg/mL

storage temp.

10-30°C

InChI

1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1

InChI key

BZQFBWGGLXLEPQ-REOHCLBHSA-N

General description

A potent agonist for group III mGlu receptor subtype 4, 6, and 8 (EC50 = 1-4, 3, and 2 µM for mGlu4, mGlu6, mGlu8, respectively); but not for subtype 7 (EC50 = 160-1200 µM). Inhibits proliferation and enhances neuronal differentiation in progenitor cells. Widely used to study presynaptic inhibitory modulation of the excitatory glutamatergic transmission at retina and central nervous systems.
A potent agonist for group III mGlu receptor subtype 4, 6, and 8 (EC50 = 1-4, 3, and 2 µM for mGlu4, mGlu6, mGlu8, respectively); but not for subtype 7 (EC50 = 160-1200 µM). Inhibits proliferation and enhances neuronal differentiation in progenitor cells. Widely used to study presynaptic inhibitory modulation of the excitatory glutamatergic transmission at retina and central nervous systems.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
mGlu₄, mGlu₆, mGlu₈

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Eriksen, L., et al. 1995. Br. J. Pharmacol.116, 3279.

Thoreson, W., et al. 1995. Brain Res.676, 93.

Bruno, V., et al. 1996. Eur. J. Pharmacol.310, 61.
Saxe, J., et al. 2007. Chem. Biol.14, 1019.
Nakajima, Y., 1993. J. Biol. Chem.268, 11868.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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