5.09706
DFB
Synonym(s):
DFB, [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde, 3,3ʹ-Difluorobenzaldazine
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About This Item
Empirical Formula (Hill Notation):
C14H10F2N2
CAS Number:
Molecular Weight:
244.24
UNSPSC Code:
12352200
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 12 mg/mL
storage temp.
2-8°C
InChI
1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9-,18-10-
InChI key
YYMCVDNIIFNDJK-XFQWXJFMSA-N
General description
A positive allosteric modulator for mGlu receptor subtype 5 (EC50 = 2 - 5.3 µM). No agonistic action on mGlu5. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
mGlu₅
mGlu₅
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
OʹBrien, J., et al. 2003. Mol. Pharmacol.64, 731.
Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther.315, 1212.
Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther.315, 1212.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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