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Merck
CN

5.09706

DFB

Synonym(s):

DFB, [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde, 3,3ʹ-Difluorobenzaldazine

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About This Item

Empirical Formula (Hill Notation):
C14H10F2N2
CAS Number:
15332-10-2
Molecular Weight:
244.24
UNSPSC Code:
12352200
MDL number:
MFCD03653615

Key Documents

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Quality Level

100

InChI

1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9-,18-10-

InChI key

YYMCVDNIIFNDJK-XFQWXJFMSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 12 mg/mL

General description

A positive allosteric modulator for mGlu receptor subtype 5 (EC50 = 2 - 5.3 µM). No agonistic action on mGlu5. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
mGlu₅

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

OʹBrien, J., et al. 2003. Mol. Pharmacol.64, 731.
Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther.315, 1212.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
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Certificates of Analysis (COA)

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