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Merck
CN

513040-M

Millipore

PD 174265

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 450 pM).

Synonym(s):

PD 174265, 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline

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About This Item

Empirical Formula (Hill Notation):
C17H15BrN4O
CAS Number:
216163-53-0
Molecular Weight:
371.23
MDL number:
MFCD02179208
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 200 mg/mL

storage temp.

−20°C

SMILES string

Brc1cc(ccc1)Nc2ncnc3c2cc(cc3)NC(=O)CC

InChI

1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22)

InChI key

WUPUZEMRHDROEO-UHFFFAOYSA-N

Related Categories

General description

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).

Biochem/physiol Actions

Primary Target
EGFR tyrosine kinase activity
Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

495.3 °F

Flash Point(C)

257.4 °C

Certificates of Analysis (COA)

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